Therapeutic Drug Monitoring of Antiepileptic Drugs

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Therapeutic drug monitoring of antiepileptic drugs.

Commonly used conventional antiepileptic drugs for pharmacotherapy in epilepsy are phenytoin, carbamazepine and valproic acid. These drugs have complex pharmacokinetic properties leading to fluctuation in their plasma level at given same therapeutic dose. The present study was done to monitor their plasma levels. A prospective observational study was conducted at National Public Health Laborato...

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Therapeutic drug monitoring of antiepileptic drugs by use of saliva.

Blood (serum/plasma) antiepileptic drug (AED) therapeutic drug monitoring (TDM) has proven to be an invaluable surrogate marker for individualizing and optimizing the drug management of patients with epilepsy. Since 1989, there has been an exponential increase in AEDs with 23 currently licensed for clinical use, and recently, there has been renewed and extensive interest in the use of saliva as...

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A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs

Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...

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Therapeutic monitoring of antiepileptic drugs for epilepsy.

BACKGROUND The aim of drug treatment for epilepsy is to prevent seizures without causing adverse effects. To achieve this, drug dosages need to be individualised. Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients. OBJECTIVES To review the evidence regarding the effects of therapeutic drug monitor...

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Therapeutic Drug Monitoring of Antiepileptic Medications

Medications used to treat and prevent seizures (antiepileptic medications, AEMs) have been commonly managed by therapeutic drug monitoring (TDM) to optimize efficacy and avoid toxicity (Neels et al., 2004; Patsalos et al., 2008). TDM has been applied mostly to the firstgeneration AEMs that have been used clinically in the United States and Europe for several decades, namely carbamazepine, ethos...

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ژورنال

عنوان ژورنال: Journal of Nepal Medical Association

سال: 2008

ISSN: 1815-672X,0028-2715

DOI: 10.31729/jnma.294